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Rat Spag6 cDNA Clone(NM_001034960.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004440

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Gene Information

Cat. No. CDFR004440
Description NativeORF clone of Rattus norvegicus sperm associated antigen 6 (Spag6) as transfection-ready DNA NM_001034960.1
Product Type cDAN Clone
Gene Abbr Spag6
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene SPAG6
Background The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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