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Rat Socs1 ORF Clone(NM_145879.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR381618

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Gene Information

Cat. No. CDCR381618
Product Type ORF Clone
Gene Abbr Socs1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 639 bp
Vector pCMV6-Entry
Target Gene SOCS1
Background This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
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