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Rat Slc46a1 cDNA Clone(NM_001013969.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003046

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Gene Information

Cat. No. CDFR003046
Description NativeORF clone of Rattus norvegicus solute carrier family 46, member 1 (Slc46a1) as transfection-ready DNA NM_001013969.1
Product Type cDAN Clone
Gene Abbr Slc46a1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene SLC46A1
Background This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
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