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Rat Slc12a3 cDNA Clone(NM_019345.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011585

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Gene Information

Cat. No. CDFR011585
Description NativeORF clone of Rattus norvegicus solute carrier family 12 (sodium/chloride transporters), member 3 (Slc12a3) as transfection-ready DNA NM_019345.3
Product Type cDAN Clone
Gene Abbr Slc12a3
Species Rat
Vector pCMV6Entry
Target Gene SLC12A3
Background This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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