Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR011585
| Cat. No. | CDFR011585 |
| Description | NativeORF clone of Rattus norvegicus solute carrier family 12 (sodium/chloride transporters), member 3 (Slc12a3) as transfection-ready DNA NM_019345.3 |
| Product Type | cDAN Clone |
| Gene Abbr | Slc12a3 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | SLC12A3 |
| Background | This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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