Rat Shank3 cDNA Clone(NM_021676.1)

Name: Rat Shank3 cDNA Clone(NM_021676.1)
SKU: CDFR011725
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011725

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Product Information

Gene Information

Cat. No.	CDFR011725
Description	NativeORF clone of Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3) as transfection-ready DNA NM_021676.1
Product Type	cDAN Clone
Gene Abbr	Shank3
Species	Rat
Vector	pCMV6Entry

Target Gene

SHANK3

Background

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]

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