Rat Shank2 ORF Clone(NM_201350.1)

Name: Rat Shank2 ORF Clone(NM_201350.1)
SKU: CDCR382360
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR382360

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Product Information

Gene Information

Cat. No.	CDCR382360
Product Type	ORF Clone
Gene Abbr	Shank2
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	5520 bp
Vector	pCMV6-Entry

Target Gene

SHANK2

Background

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

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