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Rat Sf1 ORF Clone(NM_001110793.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR376312

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Gene Information

Cat. No. CDCR376312
Product Type ORF Clone
Gene Abbr Sf1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1920 bp
Vector pCMV6-Entry
Target Gene SF1
Background This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
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