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Rat Serpini1 cDNA Clone(NM_053779.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013527

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Gene Information

Cat. No. CDFR013527
Description NativeORF clone of Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1) as transfection-ready DNA NM_053779.1
Product Type cDAN Clone
Gene Abbr Serpini1
Species Rat
Vector pCMV6Entry
Target Gene SERPINI1
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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