Rat Serpinc1 cDNA Clone(NM_001012027.1)

Name: Rat Serpinc1 cDNA Clone(NM_001012027.1)
SKU: CDFR002455
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002455

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Product Information

Gene Information

Cat. No.	CDFR002455
Description	NativeORF clone of Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 (Serpinc1) as transfection-ready DNA NM_001012027.1
Product Type	cDAN Clone
Gene Abbr	Serpinc1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

SERPINC1

Background

The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]

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