Rat Sars2 cDNA Clone(NM_001106240.1)

Name: Rat Sars2 cDNA Clone(NM_001106240.1)
SKU: CDFR005995
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR005995

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Product Information

Gene Information

Cat. No.	CDFR005995
Description	NativeORF clone of Rattus norvegicus seryl-tRNA synthetase 2, mitochondrial (Sars2), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001106240.1
Product Type	cDAN Clone
Gene Abbr	Sars2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

SARS2

Background

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

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