Rat Safb cDNA Clone(NM_022394.1)

Name: Rat Safb cDNA Clone(NM_022394.1)
SKU: CDFR011843
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011843

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Product Information

Gene Information

Cat. No.	CDFR011843
Description	NativeORF clone of Rattus norvegicus scaffold attachment factor B (Safb) as transfection-ready DNA NM_022394.1
Product Type	cDAN Clone
Gene Abbr	Safb
Species	Rat
Vector	pCMV6Entry

Target Gene

SAFB

Background

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

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