Rat Rpa1 cDNA Clone(NM_001047843.1)

Name: Rat Rpa1 cDNA Clone(NM_001047843.1)
SKU: CDFR004856
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004856

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Product Information

Gene Information

Cat. No.	CDFR004856
Description	NativeORF clone of Rattus norvegicus replication protein A1 (Rpa1) as transfection-ready DNA NM_001047843.1
Product Type	cDAN Clone
Gene Abbr	Rpa1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

RPA1

Background

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]

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