Rat Robo3 cDNA Clone(NM_001108135.1)

Name: Rat Robo3 cDNA Clone(NM_001108135.1)
SKU: CDFR007797
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR007797

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Product Information

Gene Information

Cat. No.	CDFR007797
Description	NativeORF clone of Rattus norvegicus roundabout homolog 3 (Drosophila) (Robo3) as transfection-ready DNA NM_001108135.1
Product Type	cDAN Clone
Gene Abbr	Robo3
Species	Rat
Vector	pCMV6Entry

Target Gene

ROBO3

Background

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019]

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