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Rat Rnf20 cDNA Clone(NM_001107929.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR007463

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Gene Information

Cat. No. CDFR007463
Description NativeORF clone of Rattus norvegicus ring finger protein 20 (Rnf20) as transfection-ready DNA NM_001107929.2
Product Type cDAN Clone
Gene Abbr Rnf20
Species Rat
Vector pCMV6Entry
Target Gene RNF20
Background The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
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