Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR013512
| Cat. No. | CDFR013512 |
| Description | NativeORF clone of Rattus norvegicus regulator of G-protein signaling 14 (Rgs14) as transfection-ready DNA NM_053764.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Rgs14 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | RGS14 |
| Background | This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
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