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Rat Rgs14 cDNA Clone(NM_053764.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013512

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Gene Information

Cat. No. CDFR013512
Description NativeORF clone of Rattus norvegicus regulator of G-protein signaling 14 (Rgs14) as transfection-ready DNA NM_053764.1
Product Type cDAN Clone
Gene Abbr Rgs14
Species Rat
Vector pCMV6Entry
Target Gene RGS14
Background This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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