Rat Rfx5 ORF Clone(NM_001107694.1)

Name: Rat Rfx5 ORF Clone(NM_001107694.1)
SKU: CDCR374415
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR374415

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Product Information

Gene Information

Cat. No.	CDCR374415
Product Type	ORF Clone
Gene Abbr	Rfx5
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2046 bp
Vector	pCMV6-Entry

Target Gene

RFX5

Background

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]

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