Rat Ren cDNA Clone(NM_012642.4)

Name: Rat Ren cDNA Clone(NM_012642.4)
SKU: CDFR010460
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010460

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Product Information

Gene Information

Cat. No.	CDFR010460
Description	NativeORF clone of Rattus norvegicus renin (Ren) as transfection-ready DNA NM_012642.4
Product Type	cDAN Clone
Gene Abbr	Ren
Species	Rat
Vector	pCMV6Entry

Target Gene

REN

Background

This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]

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