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Rat Rbfox1 cDNA Clone(NM_001106974.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006687

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Gene Information

Cat. No. CDFR006687
Description NativeORF clone of Rattus norvegicus ataxin 2 binding protein 1 (A2bp1) as transfection-ready DNA NM_001106974.2
Product Type cDAN Clone
Gene Abbr Rbfox1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene RBFOX1
Background The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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