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Rat Rassf1 cDNA Clone(NM_001037555.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004582

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Gene Information

Cat. No. CDFR004582
Description NativeORF clone of Rattus norvegicus Ras association (RalGDS/AF-6) domain family member 1 (Rassf1), transcript variant 1 as transfection-ready DNA NM_001037555.1
Product Type cDAN Clone
Gene Abbr Rassf1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene RASSF1
Background This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
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