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Rat Rasd2 cDNA Clone(NM_133568.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR014085

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Gene Information

Cat. No. CDFR014085
Description NativeORF clone of Rattus norvegicus RASD family, member 2 (Rasd2) as transfection-ready DNA NM_133568.1
Product Type cDAN Clone
Gene Abbr Rasd2
Species Rat
Vector pCMV6Entry
Target Gene RASD2
Background This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
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