Rat Ptpn21 cDNA Clone(NM_133545.1)

Name: Rat Ptpn21 cDNA Clone(NM_133545.1)
SKU: CDFR014064
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014064

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Product Information

Gene Information

Cat. No.	CDFR014064
Description	NativeORF clone of Rattus norvegicus protein tyrosine phosphatase, non-receptor type 21 (Ptpn21) as transfection-ready DNA NM_133545.1
Product Type	cDAN Clone
Gene Abbr	Ptpn21
Species	Rat
Vector	pCMV6Entry

Target Gene

PTPN21

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

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