Rat Psmd2 cDNA Clone(NM_001031639.1)

Name: Rat Psmd2 cDNA Clone(NM_001031639.1)
SKU: CDFR004175
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004175

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Product Information

Gene Information

Cat. No.	CDFR004175
Description	NativeORF clone of Rattus norvegicus proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (Psmd2) as transfection-ready DNA NM_001031639.1
Product Type	cDAN Clone
Gene Abbr	Psmd2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

PSMD2

Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

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