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Rat Psmb11 cDNA Clone(NM_001106032.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005805

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Gene Information

Cat. No. CDFR005805
Description NativeORF clone of Rattus norvegicus proteasome (prosome, macropain) subunit, beta type, 11 (Psmb11) as transfection-ready DNA NM_001106032.1
Product Type cDAN Clone
Gene Abbr Psmb11
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene PSMB11
Background Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]
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