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Rat Psenen ORF Clone(NM_001008764.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR368962

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Product Information

Gene Information

Cat. No. CDCR368962
Product Type ORF Clone
Gene Abbr Psenen
Species Rat
Tag C-terminal Myc-DDK
ORF Size 306 bp
Vector pCMV6-Entry
Target Gene PSENEN
Background Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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