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Rat Prss12 cDNA Clone(NM_053504.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013232

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Gene Information

Cat. No. CDFR013232
Description NativeORF clone of Rattus norvegicus protease, serine, 12 neurotrypsin (motopsin) (Prss12) as transfection-ready DNA NM_053504.1
Product Type cDAN Clone
Gene Abbr Prss12
Species Rat
Vector pCMV6Entry
Target Gene PRSS12
Background This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
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