Rat Prkag3 cDNA Clone(NM_001106921.1)

Name: Rat Prkag3 cDNA Clone(NM_001106921.1)
SKU: CDFR006647
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006647

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Product Information

Gene Information

Cat. No.	CDFR006647
Description	NativeORF clone of Rattus norvegicus protein kinase, AMP-activated, gamma 3 non-catalytic subunit (Prkag3) as transfection-ready DNA NM_001106921.1
Product Type	cDAN Clone
Gene Abbr	Prkag3
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

PRKAG3

Background

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]

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