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Rat Prkab2 ORF Clone(NM_022627.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379105

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Product Information

Gene Information

Cat. No. CDCR379105
Product Type ORF Clone
Gene Abbr Prkab2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 816 bp
Vector pCMV6-Entry
Target Gene PRKAB2
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
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