Rat Prcp cDNA Clone(NM_001106281.2)

Name: Rat Prcp cDNA Clone(NM_001106281.2)
SKU: CDFR006039
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006039

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Product Information

Gene Information

Cat. No.	CDFR006039
Description	NativeORF clone of Rattus norvegicus prolylcarboxypeptidase (angiotensinase C) (Prcp) as transfection-ready DNA NM_001106281.2
Product Type	cDAN Clone
Gene Abbr	Prcp
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

PRCP

Background

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

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