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Rat Ppp1r15b cDNA Clone(NM_001107175.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006851

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Gene Information

Cat. No. CDFR006851
Description NativeORF clone of Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 15b (Ppp1r15b) as transfection-ready DNA NM_001107175.1
Product Type cDAN Clone
Gene Abbr Ppp1r15b
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene PPP1R15B
Background This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
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