Rat Ppm1f cDNA Clone(NM_175755.2)

Name: Rat Ppm1f cDNA Clone(NM_175755.2)
SKU: CDFR014863
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014863

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Product Information

Gene Information

Cat. No.	CDFR014863
Description	NativeORF clone of Rattus norvegicus protein phosphatase 1F (PP2C domain containing) (Ppm1f) as transfection-ready DNA NM_175755.2
Product Type	cDAN Clone
Gene Abbr	Ppm1f
Species	Rat
Vector	pCMV6Entry

Target Gene

PPM1F

Background

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

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