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Rat Polh ORF Clone(NM_001108204.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR374885

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Gene Information

Cat. No. CDCR374885
Product Type ORF Clone
Gene Abbr Polh
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2070 bp
Vector pCMV6-Entry
Target Gene POLH
Background This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
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