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Rat Pnp cDNA Clone(NM_001106031.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005804

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Gene Information

Cat. No. CDFR005804
Description NativeORF clone of Rattus norvegicus nucleoside phosphorylase (Np) as transfection-ready DNA NM_001106031.1
Product Type cDAN Clone
Gene Abbr Pnp
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene PNP
Background This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
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