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Rat Pkn1 cDNA Clone(NM_017175.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011227

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Gene Information

Cat. No. CDFR011227
Description NativeORF clone of Rattus norvegicus protein kinase N1 (Pkn1) as transfection-ready DNA NM_017175.2
Product Type cDAN Clone
Gene Abbr Pkn1
Species Rat
Vector pCMV6Entry
Target Gene PKN1
Background The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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