Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR011227
| Cat. No. | CDFR011227 |
| Description | NativeORF clone of Rattus norvegicus protein kinase N1 (Pkn1) as transfection-ready DNA NM_017175.2 |
| Product Type | cDAN Clone |
| Gene Abbr | Pkn1 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | PKN1 |
| Background | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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