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Rat Pik3c2b cDNA Clone(NM_001105951.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005727

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Gene Information

Cat. No. CDFR005727
Description NativeORF clone of Rattus norvegicus phosphoinositide-3-kinase, class 2, beta polypeptide (Pik3c2b) as transfection-ready DNA NM_001105951.1
Product Type cDAN Clone
Gene Abbr Pik3c2b
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene PIK3C2B
Background The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
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