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Rat Pfkfb4 cDNA Clone(NM_019333.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011420

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Gene Information

Cat. No. CDFR011420
Description NativeORF clone of Rattus norvegicus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (Pfkfb4) as transfection-ready DNA NM_019333.1
Product Type cDAN Clone
Gene Abbr Pfkfb4
Species Rat
Vector pCMV6Entry
Target Gene PFKFB4
Background The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
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