Rat Pfkfb3 cDNA Clone(NM_057135.1)

Name: Rat Pfkfb3 cDNA Clone(NM_057135.1)
SKU: CDFR013743
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013743

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Product Information

Gene Information

Cat. No.	CDFR013743
Description	NativeORF clone of Rattus norvegicus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3) as transfection-ready DNA NM_057135.1
Product Type	cDAN Clone
Gene Abbr	Pfkfb3
Species	Rat
Vector	pCMV6Entry

Target Gene

PFKFB3

Background

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

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