Rat Pex19 cDNA Clone(NM_001134777.1)

Name: Rat Pex19 cDNA Clone(NM_001134777.1)
SKU: CDFR010002
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010002

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Product Information

Gene Information

Cat. No.	CDFR010002
Description	NativeORF clone of Rattus norvegicus peroxisomal biogenesis factor 19 (Pex19), transcript variant 2 as transfection-ready DNA NM_001134777.1
Product Type	cDAN Clone
Gene Abbr	Pex19
Species	Rat
Vector	pCMV6Entry

Target Gene

PEX19

Background

This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

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