Rat Pdha1 ORF Clone(NM_001004072.2)

Name: Rat Pdha1 ORF Clone(NM_001004072.2)
SKU: CDCR368313
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR368313

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Product Information

Gene Information

Cat. No.	CDCR368313
Product Type	ORF Clone
Gene Abbr	Pdha1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1173 bp
Vector	pCMV6-Entry

Target Gene

PDHA1

Background

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

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