Rat Pcsk6 cDNA Clone(NM_012999.1)

Name: Rat Pcsk6 cDNA Clone(NM_012999.1)
SKU: CDFR010806
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010806

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Product Information

Gene Information

Cat. No.	CDFR010806
Description	NativeORF clone of Rattus norvegicus proprotein convertase subtilisin/kexin type 6 (Pcsk6) as transfection-ready DNA NM_012999.1
Product Type	cDAN Clone
Gene Abbr	Pcsk6
Species	Rat
Vector	pCMV6Entry

Target Gene

PCSK6

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

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