Rat Pcsk1 ORF Clone(NM_017091.2)

Name: Rat Pcsk1 ORF Clone(NM_017091.2)
SKU: CDCR378060
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR378060

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Product Information

Gene Information

Cat. No.	CDCR378060
Product Type	ORF Clone
Gene Abbr	Pcsk1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2259 bp
Vector	pCMV6-Entry

Target Gene

PCSK1

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]

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