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Rat Pcdhgc3 cDNA Clone(NM_053943.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013652

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Gene Information

Cat. No. CDFR013652
Description NativeORF clone of Rattus norvegicus protocadherin gamma subfamily C, 3 (Pcdhgc3) as transfection-ready DNA NM_053943.1
Product Type cDAN Clone
Gene Abbr Pcdhgc3
Species Rat
Vector pCMV6Entry
Target Gene PCDHGC3
Background This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
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