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Rat Pc cDNA Clone(NM_012744.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010557

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Gene Information

Cat. No. CDFR010557
Description NativeORF clone of Rattus norvegicus pyruvate carboxylase (Pc), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_012744.2
Product Type cDAN Clone
Gene Abbr Pc
Species Rat
Vector pCMV6Entry
Target Gene PC
Background This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
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