Rat Pank2 cDNA Clone(NM_001106513.1)

Name: Rat Pank2 cDNA Clone(NM_001106513.1)
SKU: CDFR005693
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR005693

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Product Information

Gene Information

Cat. No.	CDFR005693
Description	NativeORF clone of Rattus norvegicus pantothenate kinase 2 (Hallervorden-Spatz syndrome) (Pank2), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001106513.1
Product Type	cDAN Clone
Gene Abbr	Pank2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

PANK2

Background

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

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