Rat Padi2 cDNA Clone(NM_017226.1)

Name: Rat Padi2 cDNA Clone(NM_017226.1)
SKU: CDFR011276
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011276

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Product Information

Gene Information

Cat. No.	CDFR011276
Description	NativeORF clone of Rattus norvegicus peptidyl arginine deiminase, type II (Padi2) as transfection-ready DNA NM_017226.1
Product Type	cDAN Clone
Gene Abbr	Padi2
Species	Rat
Vector	pCMV6Entry

Target Gene

PADI2

Background

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

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