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Rat Ogdh cDNA Clone(NM_001017461.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003463

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Gene Information

Cat. No. CDFR003463
Description NativeORF clone of Rattus norvegicus oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001017461.1
Product Type cDAN Clone
Gene Abbr Ogdh
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene OGDH
Background This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
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