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Rat Nr1h2 ORF Clone(NM_031626.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379783

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Product Information

Gene Information

Cat. No. CDCR379783
Product Type ORF Clone
Gene Abbr Nr1h2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1332 bp
Vector pCMV6-Entry
Target Gene NR1H2
Background The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
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