Rat Nr0b2 ORF Clone(NM_057133.1)

Name: Rat Nr0b2 ORF Clone(NM_057133.1)
SKU: CDCR380775
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR380775

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Product Information

Gene Information

Cat. No.	CDCR380775
Product Type	ORF Clone
Gene Abbr	Nr0b2
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	783 bp
Vector	pCMV6-Entry

Target Gene

NR0B2

Background

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

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