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Rat Notch4 cDNA Clone(NM_001002827.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001225

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Gene Information

Cat. No. CDFR001225
Description NativeORF clone of Rattus norvegicus Notch homolog 4 (Drosophila) (Notch4) as transfection-ready DNA NM_001002827.1
Product Type cDAN Clone
Gene Abbr Notch4
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene NOTCH4
Background This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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