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Rat Necab3 ORF Clone(NM_001098724.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR372199

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Gene Information

Cat. No. CDCR372199
Product Type ORF Clone
Gene Abbr Necab3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1056 bp
Vector pCMV6-Entry
Target Gene NECAB3
Background The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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