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Rat Ncf4 cDNA Clone(NM_001127304.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR009524

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Gene Information

Cat. No. CDFR009524
Description NativeORF clone of Rattus norvegicus neutrophil cytosolic factor 4 (Ncf4) as transfection-ready DNA NM_001127304.1
Product Type cDAN Clone
Gene Abbr Ncf4
Species Rat
Vector pCMV6Entry
Target Gene NCF4
Background The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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